Interaction of Alamethicin Pores in DMPC Bilayers
نویسندگان
چکیده
منابع مشابه
Interaction of alamethicin pores in DMPC bilayers.
We have investigated the x-ray scattering signal of highly aligned multilayers of the zwitterionic lipid 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine containing pores formed by the antimicrobial peptide alamethicin as a function of the peptide/lipid ratio. We are able to obtain information on the structure factor of the pore fluid, which then yields the interaction potential between pores i...
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Calcium-induced inactivation of alamethicin in asymmetric lipid bilayers
This paper discusses a calcium-dependent inactivation of alamethicin-induced conductance in asymmetric lipid bilayers. The bilayers used were formed with one leaflet of phosphatidyl ethanolamine (PE) and one of phosphatidyl serine (PS). Calcium, initially confined to the neutral lipid (PE) side, can pass through the open alamethicin channel to the negative lipid (PS) side, where it can bind to ...
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Density functional theory is used to study pore formation in bilayer membranes in amphiphile solutions. The theory is applied to an interaction site model of surfactant molecules composed of two tangent spheres, with effective interactions that mimic the effect of the solvation forces induced by water. The free energy functional of the system exhibits local minima corresponding to planar struct...
متن کاملCholesterol orientation and tilt modulus in DMPC bilayers.
We performed molecular dynamics (MD) simulations of hydrated bilayers containing mixtures of dimyristoylphosphatidylcholine (DMPC) and cholesterol at various ratios, to study the effect of cholesterol concentration on its orientation, and to characterize the link between cholesterol tilt and overall phospholipid membrane organization. The simulations show a substantial probability for cholester...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2007
ISSN: 0006-3495
DOI: 10.1529/biophysj.106.101204